knee osteoarthritis
Conditions
Interventions
intravenous group:1g of TXA intravenously inject ten minutes before skin incision, and 1g at 3h and 6h postoperatively
topical irrigation group:3g of TXA in 75 ml of normal saline and irrigate the joint cavity for 5 min before tourniquet deflation.
topical injection group:After the joint capsule closure, 3g of TXA in 75 ml of normal saline and inject into the periarticular soft tissue before wound closure.
drainage injection group:After the wound closure, 3g of TXA in 75 ml of normal saline inject into the articular cavity through a drainage tube
control group:Patients undergoing TKA without TXA
Sponsors
General Hospital of Ningxia Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. The patients with knee osteoarthritis ongoing total knee arthroplasty. 2. Aged 18 -100 years.
Exclusion criteria
Exclusion criteria: 1. Patients allergic to TXA; 2. With preoperative hepatic or renal dysfunction; 3. With serious cardiac or respiratory disease, including coronary artery stent placement or bypass; 4. With congenital or acquired coagulopathy, as evidenced by an international normalized ratio (INR) of >1.4 or a partial thromboplastin time (PTT) of > 1.4 times normal; 5. With a preoperative platelet count of < 150,000/mm3; 6. With history of a prothrombotic condition; 7. Pregnancy or breastfeeding; 8. Patients with infectious arthritis; 9. With a preoperative hemoglobin level of <10 g/dL.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood loss;blood transfusion rate;Plasminogen activator inhibitor 1, PAI-1;prothrombin fragment 1+2, F1+2;thrombin-antithronbin complex, TAT; | — |
Secondary
| Measure | Time frame |
|---|---|
| Drainage volume;D-dimer;wound complication;length of hospital stay;deep vein thrombosis, DVT; | — |
Countries
China
Contacts
Public ContactJin Qunhua
General Hospital of Ningxia Medical University
Outcome results
None listed