Essential Hypertension
Conditions
Interventions
Sponsors
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 18-75 years old; 2. Patients who meet the western diagnostic standard of grade 2 hypertension and the TCM syndrome differentiation standard of hyperactivity of liver Yang syndrome; 3. The patients with grade 2 essential hypertension and moderate risk are identified according to the blood pressure level and cardiovascular risk stratification of hypertension, whose blood pressure meet any one of the following three criteria: (1) Systolic blood pressure 160-179mmHg and/or diastolic blood pressure 100-109 mmHg, no previous use of any antihypertensive drugs, no complications such as heart, brain and kidney; (2) Patients who have been clearly diagnosed as essential hypertension and whose blood pressure is still not up to the standard after 3 months of improved lifestyle or other forms of non-drug therapy, maintaining the blood pressure at 160-179/100-109mmhg; (3) Patients who have been clearly diagnosed as essential hypertension and whose blood pressure is still not up to the standard after 3 months of improved lifestyle or other forms of non-drug therapy and oral antihypertensive medication, maintaining the blood pressure at 160-179/100-109mmhg; 4. Patients whose course of hypertension must be more than 3 months; 5. Patients with informed consent and signing informed consent.
Exclusion criteria
Exclusion criteria: 1. With various secondary hypertension; 2. Patients Received other new drugs in the past 3 months; 3. Patients with moderate or severe diabetes or patients with myocardial infarction or cerebral apoplexy within half a year; 4. Pregnant or pregnant women and women in lactation; 5. Patients who are allergic to a variety of drugs or allergic constitution; 6. Patients with mental illness, alcoholism and/or psychoactive substance abuse and dependence; 7. With combining with the following organ damage or disease, angina pectoris, heart failure, transient brain, hypertensive encephalopathy, retinopathy (with or without apparent papillary edema), plasma creatinine concentration of 2.0 mg/dl or more renal function failure, liver failure, or aortic aneurysm, aortic dissecting aneurysm artery occlusive disease symptoms. 8. At present, patients who have taken valsartan 80mg/amlodipine 5mg and other ARB/CCB compound drugs, and whose blood pressure is still level 2 and above.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Syndrome score of TCM;Blood pressure;Blood fat;Blood sugar;Urinary microalbumin;Uric acid;Homocysteine(HCY);Hypersensitive c-reactive protein; | — |
Countries
China
Contacts
Public ContactYunlun Li
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Outcome results
None listed