Delayed encephalopathy after acute carbon monoxide poisoning
Conditions
Interventions
experimental group:NBP and DXM combined with HBO
control group:DXM and HBO
Sponsors
Heze Municipal Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: Patients meeting the following criteria were included: 1. patients with a history of CO exposure; 2. Patients with a Mini-Mental State Examination (MMSE) score of no more than 24; 3. Patients with clinical symptoms of DEACMP occurring after 2-60 days of a latent period without any clinical manifestation of acute CO poisoning; 4. Patients with neuroimaging evidence of demyelination lesions of bilateral cerebral white matter in brain MRI; 5. Patients who provid written or oral informed consent and complet all of the treatment programme and a follow-up plan.
Exclusion criteria
Exclusion criteria: The exclusion criteria were as follows: 1. With history of severe allergy to NBP or DXM; 2. With history of anxiety,depression and other mental illness; 3. Patients who had chronic hepatic or renal insufficiency; 4. With intellectual impairment; 5. With stroke; 6. With systemic infection or severe local infection; 7. With coagulation disorders; 8. With HIV,hepatitis B virus (HBV)/C virus (HCV); 9. With syphilis; 10. With genetic disorders or pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the Mini-Mental State Examination;the Montreal cognitive assessment;the Barthel index of activities of daily living;the Hamilton Anxiety Scale;Hamilton Depression Scale; | — |
Countries
China
Contacts
Public ContactChen Yankun
Heze Municipal Hospital
Outcome results
None listed