anxiety
Conditions
Interventions
General anesthesia test group 1 (GD1):dexmedetomidine was applied intraoperatively and dexmedetomidine was applied in postoperative analgesic pump
GD group 2:dexmedetomide was applied intraoperatively and dexmedetomide was not applied in postoperative analgesic pump
GC group:dexmedetomidine was not applied
PD group 1:dexmedetomidine was applied intraoperatively and dexmedetomidine was applied in postoperative analgesic pump
Group PD1:dexmedetomidine was applied intraoperatively and dexmedetomidine was applied in postoperative analgesic pump
PD group 2 :dexmedetomidine was applied intraoperatively but dexmedetomidine was not applied in postoperative analgesic pump
PC group :dexmedetomidine was not applied
Group PD2:dexmedetomidine was applied intraoperatively but dexmedetomidine was not applied in postoperative analgesic pump
Sponsors
He'nan Provincial People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Older than 65 years; 2. Non-cardiac surgery was scheduled at an elective time, with a duration of more than 2 hours;Operation: knee and hip replacement; 3. ASA grades are I~III; 4. The hospital stay is expected to be longer than 7 days.
Exclusion criteria
Exclusion criteria: 1. Refuse to participate; 2. Preoperative history of schizophrenia, epilepsy, Parkinson's disease or myasthenia gravis; 3. Communication barrier caused by coma, severe dementia, language barrier and other reasons before the operation; 4. Preoperative left ventricular ejection fraction < 30%, sinus disease syndrome, sinus severe bradycardia (< 50 times/min), or second degree or above atrioventricular block without pacemaker, severe coronary lesions; 5. Severe liver dysfunction (child-pugh C category); 6. Severe renal insufficiency, renal failure and need of dialysis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium;prognosis; | — |
Countries
China
Contacts
Public ContactLu Li
He'nan Provincial People's Hospital
Outcome results
None listed