Novel Coronavirus Pneumonia (COVID-19)
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: This study intends to select surveillance cases, suspected cases and diagnosed cases of COVID-19 for children aged 0-18 who were admitted to the department of Pediatrics in Tongji Hospital from December 2019 to June 2020. 1. Epidemiological classification: all children are divided into three levels: high, medium and low risk according to their epidemiological history: (1) high risk: participant was close to suspected or confirmed case of COVID-19 within 14 days before the onset of illness; (2) intermediate risk: cluster of COVID-19 cases in the place of residence or the community; (3) low risk: The residence or community has no cluster cases or not from epidemic area; 2. Surveillance cases: high-risk children who do not show symptoms are surveillance cases, and intermediate or low risk children who have any of the following symptoms are surveillance cases: (1) Fever; (2) Respiratory symptoms or weakness, nausea, vomiting, abdominal discomfort and diarrhea. 3. Suspected cases: Newborns born to pregnant women diagnosed with COVID-19 are suspected cases. High-risk children and surveillance cases at intermediate and low risk are suspected cases after excluding influenza (standardized administration of oseltamivir phosphate for 2 days) and other common respiratory pathogen infections who meet any two of the following three conditions are suspected cases: (1) persistent Fever, obvious respiratory symptoms, shortness of breath or decreased pulse oxygen saturation, or gastrointestinal manifestations such as nausea, vomiting, abdominal discomfort and diarrhea; (2) Laboratory tests: normal or decreased white blood cells, decreased lymphocyte count, normal or slightly elevated CRP; (3) pulmonary imaging with signs of COVID-19. 4. Confirmed cases: meeting the criteria for suspected cases, positive result on COVID-19 nucleic acid test with samples of respiratory swabs or secretions, blood, feces and urine ; highly homologous viral gene sequencing with known COVID-19.
Exclusion criteria
Exclusion criteria: (1) Exclude influenza virus, parainfluenza virus, adenovirus, respiratory syncytial virus, rhinovirus, human metapneumovirus, boca virus, and other known viral respiratory infections; (2) Exclude pneumonia caused by atypical microorganisms such as Mycoplasma pneumoniae, Legionella, fungal pneumonia, and tuberculosis; (3) Exclude children with basic diseases who have invasive fungal infections; (4) Exclude children with no clear infectious etiology who have non-infectious diseases such as vasculitis, dermatomyositis, idiopathic interstitial lung disease, and organizing pneumonia; (5) Exclude If the guardian of the child does not agree to sign the informed consent form or collect information.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Child Stress Disorders Checklist evaluation;Achenbach children's behavior checklist evaluation;children's severe emotional disorder and psychological crisis during inpatient treatment; | — |
Countries
China
Contacts
Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology