Cerebrovascular disease
Conditions
Interventions
dual antiplatelet group:Cilostazol, Aspirin and standard therapy
mono antiplatelet group:Aspirin and standard therapy
Sponsors
Maoming People's Hospital
Eligibility
Sex/Gender
All
Age
40 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1) In accordance with the diagnostic criteria of ischemic stroke according to the Chinese Guidelines for Cerebrovascular Disease Prevention and Treatment in 2018, pure motor hemiplegia with NIHSS score 4-8; 2) Within 24 hours of stroke onset; 3) First or previous stroke patients with a history of ischemic stroke (mRS score 0-1); 4) Age 40-85 years old; 5) Brain CT excluded cerebral hemorrhage, or CTA excluded >50% of the large vascular stenosis or occlusion; 6) MRI conformed to the definition of BAD: the lenticulostriate arteries BAD: three or more consecutive axial MRI diffusion-weighted imaging (DWI) transverse slices in the white matter of the LSA territory (internal capsule and/or corona radiata)or unilateral infarcts extending to the basal surface of the pons in the PPA territory (ventral pons) 7) Patients or their guardians signed informed consents.
Exclusion criteria
Exclusion criteria: 1) Receiving atepase intravenous thrombolysis; 2) Cardiogenic embolism; 3) Head CTA or MRA excluded middle cerebral artery M1 or basilar artery with symptomatic intracranial artery stenosis more than 50%; 4) Patients with mental disorders or cognitive impairment who were unable to live independently; 5) Patients who refused to participate in the study; and 6) Other patients who were not suitable for study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Early neurological deterioration within 7 days after stoke onset; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neurological function prognosis 14 days after onset;Favorable neurological prognosis 28 days after onset;New clinical vascular events (stroke, myocardial infarction or vascular death) within 28 days after onset of disease; | — |
Countries
China
Contacts
Public ContactHao Li
Department of Neurology, Maoming People's Hospital
Outcome results
None listed