2019 novel coronavirus pneumonia (COVID-19)
Conditions
Interventions
Sponsors
Eligibility
Inclusion criteria
Inclusion criteria: 1. Aged > 18 years; 2. COVID-19 coronavirus nucleic acid positive (including throat swabs, sputum, bronchoalveolar lavage fluid, stool and other specimens); 3. Chest imaging has clear viral pneumonia changes; 4. Respiratory dysfuntion, which meets the following criteria: (1) Respiratory distress, respiratory rate (RR) is greater than 30 times /min; (2) Finger pulse oxygen saturation <= 93% at resting state; (3) PaO2 / FiO2 <= 300 mmHg (1 mmHg = 0.133 kPa); and (4) Pulmonary imaging showed that the lesions progressed more than 50% within 24-48 hours.
Exclusion criteria
Exclusion criteria: 1. Children and pregnant women; 2. Serious cardiopulmonary diseases (chronic obstructive pulmonary disease, acute coronary syndrome, dilated cardiomyopathy, congenital heart disease, chronic pulmonary hypertension, etc.); 3. End stage of malignant tumor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Lung ultrasound index;Right ventricular function ultrasound index;Left ventricular function ultrasound index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Mechanical ventilation time (days);ICU stay (days);Total hospitalization time (days);28-day all-cause mortality; | — |
Countries
China
Contacts
Department of Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology