Thyroid stimulating hormone secreting pituitary adenoma
Conditions
Interventions
experimental group:Octreotide injection 0.1mg q8h
control group:no Octreotide injection
Sponsors
Department of Endocrinology, Xinqiao Hospital, the Third Military Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. All the diagnostic criteria for TSH tumor included in the study are the diagnostic criteria recommended by Chinese experts in the diagnosis and treatment of pituitary thyrotropic hormone adenoma (2017) and ETA in 2013: (1) serum FT4 and FT3 are higher than the normal range, and the serum TSH level is not inhibited; (2) functional test: octreotide test suggested that it could be inhibited; (3) genetic testing: thyroxine receptor beta gene mutation detection suggested no exact significance of the mutation;(4) MRI plain scan and enhancement in the saddle region suggested pituitary adenoma. 2. Aged 18-70 years; 3. Sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients with severe infection, trauma, surgery, heart failure, acute myocardial infarction, hypotension, hypoxia and other stress conditions; 2. Serious cardiovascular diseases, untreated hypertension and pulmonary insufficiency; 3. Participated in clinical trials of other drugs within 30 days; 4. The participant cannot participate in completing the intervention under other circumstances; 5. The researcher considers that the subjects have diseases that affect the outcome assessment or are not suitable for inclusion.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| thyroid hormones;MRI scan + enhancement in saddle region;Growth hormone and related hormones;Preoperative armour power control efficiency;Perioperative mortality;The incidence of perioperative hyperthyroidism crisis; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sex hormones;Thyrotropin receptor artibody;Thyroid ultrasound;anesthetic accident;intraoperative blood loss;Duration of operation;intraoperative blood loss;surgical complication;Time of admission to icu after surgery; | — |
Countries
China
Contacts
Public ContactLong Min
Department of Endocrinology, Translational Research Key Laboratory for Diabetes, Xinqiao Hospital, the Third Military Medical University
Outcome results
None listed