Japanese encephalitis
Conditions
Interventions
Case series:Nil
Sponsors
the 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army
Eligibility
Sex/Gender
Male
Inclusion criteria
Inclusion criteria: 1. The subjects in the test group came from the Japanese encephalitis endemic area and were bitten by mosquitoes before onset; 2. The subjects in the test group showed acute onset, fever, headache, jet-like vomiting with varying degrees of conscious disturbance, severe cases with convulsions, paralysis, and severe central respiratory failure; 3. The subjects in the test group have disappeared tendon reflexes, hyperreflexia, positive meningeal signs and pathological signs, which may be accompanied by changes in pupil size, increased blood pressure, and increased intracranial pressure; 4. The subjects in the test group had mostly white blood cells (10 ~ 20x10^9/L), neutrophil count percentage>80%, cerebrospinal fluid pressure> 200 mmH2O, clear color of cerebrospinal fluid, and white blood cell technology were mostly in the range of 50-500x10^6/L, slightly increased protein, normal sugar chloride; 5. Subjects in the test group completed serological or cerebrospinal fluid anti-Japanese Ig-M antibody testing and agreed to serological and cerebrospinal fluid proteomics-related tests; 6. The subjects in the control group were non-Japanese encephalitis patients in the same period. Because of the diagnosis, routine and biochemical examinations of serum and cerebrospinal fluid were required. Serum and cerebrospinal fluid proteomics-related tests were agreed.
Exclusion criteria
Exclusion criteria: 1. The surviving subjects during the trial failed to complete the GCS score at admission, the MMSE score at discharge, and the MRS score after 1 month; 2. Withdrew during the test or did not agree to the serological and cerebrospinal fluid anti-Japanese Ig-M antibody tests, or serological and cerebrospinal fluid proteomics-related tests; 3. The subjects and their families refused to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MMSE score at discharge;MRS score after 1 month of discharge;Serological and cerebrospinal fluid proteomic data; | — |
Secondary
| Measure | Time frame |
|---|---|
| Subject mortality; | — |
Countries
China
Contacts
Public ContactRong Yin
Neurology Department of the 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army
Outcome results
None listed