Alzheimer’s Disease
Conditions
Interventions
Gold Standard:Clinical outcome: Recommendations from the national institute on aging-alzheimer's association workgroups on diagnostic guidelines for alzheimer's disease, 2011
value 
of 
Sponsors
Huashan Hospital, Fudan University
Eligibility
Sex/Gender
All
Age
45 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Healthy control: (1) between 45 and 90 years old; (2) The researchers determined that cognitive function was normal through cognitive tests. The CDR score is 0; (3) No neurological diseases, major chronic diseases, malignant tumors or acute infectious diseases were identified by the researchers; (4) No family history of AD, no family history of neurological diseases related to cognitive impairment and movement disorder; (5) Understand and sign written informed consent prior to any assessment; (6) The female subject shall have a medical record to prove that she has undergone surgical sterilization (such as hysterectomy, bilateral ovariectomy or tubal ligation) or menopause for more than one year; If you still have the ability to conceive, you should use isolated contraception at this stage of the study; (7) Male subjects are required to use isolated contraception at this stage of the study. Male subjects are not allowed to donate sperm during the study period; (8) Willing and able to cooperate with all projects of this study; 2. AD patients: (1) aged between 45 and 90 years; (2) The patient met the diagnostic criteria for AD (nia-aa 2011). CDR score >=0.5; (3) MSE score <=25; (4) Brain MRI supported the diagnosis of AD and there was no evidence of other neurological diseases; (5) Drugs used to improve the clinical symptoms of AD should be maintained at a stable dose for more than 30 days before the start of this study; (6) Informed consent signed in person by the subject or his/her legal guardian/caretaker; (7) Subject will be accompanied by paramedics if necessary. (8) Subject or its legal representative understands and signs a written informed consent prior to any evaluation; (9) The female subject shall have a medical record to prove that she has undergone surgical sterilization (such as hysterectomy, bilateral ovariectomy or tubal ligation) or menopause for more than one year; If you still have the ability to conceive, you should use isolated contraception at this stage of the study; (10) male subjects are required to take isolated contraceptive measures at this stage of the study. Male subjects are not allowed to donate sperm during the study period; (11) Willing and able to cooperate with all projects of this study.
Exclusion criteria
Exclusion criteria: 1. All subjects: (1) suffered from serious other neurological diseases, or gastrointestinal, cardiovascular, liver, kidney, blood system, tumor, endocrine, respiratory system, immune deficiency and other serious diseases; (2) Metal devices not compatible with MRI were implanted, including cardiac pacemakers, intravascular metal devices, insulin pumps, cochlear implants, nerve stimulators, and brain aneurysm clips; (3) Inability to tolerate MRI noise or hermetic phobia; (4) Received ionizing radiation outside the scope of this study due to other clinical or scientific research needs in the past year, resulting in an annual radiation exposure dose exceeding 50 mSv; (5) history of drug or alcohol abuse; (6) Pregnant or nursing women; (7) Poor venous conditions, unable to tolerate repeated venipuncture; (8) Received an experimental drug or device treatment (with unclear efficacy or safety) within 1 month; (9) Poor venous conditions, unable to tolerate repeated venipuncture; (10) may be allergic to the component of [18F]-APN-1607([18F] -PM-PBB3) injection; (11) There are any conditions that the study leader considers to be hazardous or potentially hazardous at any point in the study; 2. Patients with AD received drug therapy for category a within 3 months; received drug treatment for tau within 3 months.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Standard uptake value ratio; | — |
Countries
China
Contacts
Public ContactYihui Guan
PET Center, Huashan Hospital, Fudan University
Outcome results
None listed