Novel Coronavirus Pneumonia (COVID-19)
Conditions
Interventions
Case series:oXiris membrane
Sponsors
Department of Nephrology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Written informed consent from patients or representative; 2. Aged over 18 years; 3. Fullfill the diagnostic criteria of critically ill 2019-nCoV Respiratory Disease; 2019-nCoV diagnosis confirmed by the combination of epidemiology, clinical manifestation and virus PCR results of respiratory specimen; Critically ill patients should include one of the followings at least: 1) respritary failure, mechanical ventilation required; 2) shock; 3) complicated with other organ failures, require ICU admission.
Exclusion criteria
Exclusion criteria: 1. Respiratory failure explained with other lung conditions, including influenza virus, bacterial infection, fungi infection, non-infectious causes; 2. Comorbidities including lupus, vasculitis, APS et al. 3. Concurrent use of anti-IL6 receptor antibody; 4. Malignancy; 5. Pregnancy; 6. Potential tranfer to other hospital during the trial; 7. Other potential conditions determined by the investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28 day mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical improvement scores at Day 28;Mechanical ventilation time;vasopressor time;Duration of fever;Duration of ICU care;Cytokine measurement (TNF-alpha, IL-6, IL-10);Adverse effect; | — |
Countries
China
Contacts
Public ContactXuemei Li
Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Outcome results
None listed