Evaluating the efficacy of transcranial magnetic stimulation to improve the disturbance of consciousness through electrophysiological techniques

Arousal effects of repetitive transcranial magnetic stimulation on coma patients

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000030419

Enrollment

Unknown

Registered

2020-03-01

Start date

2020-03-01

Completion date

Unknown

Last updated

2020-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Disorders of consciousness

Interventions

TMS group:repetitive transcranial magnetic stimulation

sham TMS group:sham repetitive transcranial magnetic stimulation

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Disorders of consciousness caused by traumatic and non-traumatic causes; 2. Ages 18 to 80 years; 3. First onset, within 1-6 months; 4. Family members of the patients agreed and signed informed consent for treatment.

Exclusion criteria

Exclusion criteria: 1. Unstable vital signs; 2. Intracranial malignant tumor or unruptured aneurysm; 3. History of seizures or hydrocephalus; 4. Pregnancy; 5. Contraindications to MRI: intracranial metal implantation or installation of pacemaker,etc.; 6. Complicated severe cardiovascular and liver Patients with renal disease; 7. Other contraindications to transcranial magnetic stimulation. 8. History of drug and alcohol addiction; 9. History of sedative use; 10. History of liver and kidney failure.

Design outcomes

Primary

Measure	Time frame
somatosensory evoked potential;Brainstem auditory evoked potential;	—

Secondary

Measure	Time frame
Glasgow coma scale;Coma recovery scale-revised;Full outline of responsiveness;	—

Countries

China

Contacts

Public ContactJianmin Chen

The First Affiliated Hospital, Fujian Medical University

339728290@qq.com+86 15806033997

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026