postoperative analgesia
Conditions
Interventions
control group:Bilateral lumbar muscle block was performed with ropivacaine
experimental group 1:Bilateral quadratus lumbar muscle block was performed with ropivacaine combined with dexmedetomidine at 0.5ug/kg
experimental group 2:Bilateral quadratus lumbar muscle block was performed with ropivacaine combined with dexmedetomidine at 1.0ug/kg
experimental group 3:Bilateral quadratus lumbar muscle block was performed with ropivacaine combined with dexmedetomidine at 1.5ug/kg
Sponsors
Department of anesthesiology, the Second Affiliated Hospital of Soochow University
Eligibility
Sex/Gender
Female
Age
36 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Aged 35-60 years; 2. Perform total hysterectomy under elective general anesthesia; 3. ASA i-ii level; 4. 20 < BMI < 26.
Exclusion criteria
Exclusion criteria: 1. Previous cardiopulmonary disease, liver and kidney disease; 2. Coagulation dysfunction; 3. Local infection at the puncture site; 4. Inability to cooperate due to mental illness, cognitive impairment or mental retardation; 5. Allergies to the drugs used in the study; 6, long-term use of painkillers or sedatives patients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Dexmedetomidine Cmax, tmax, auc0-t, AUC0-8; | — |
Secondary
| Measure | Time frame |
|---|---|
| Each group received NRS score, BCS score and OAA/S score at 1h, 6h, 12h and 24h after the operation;Sedation scores, adverse reactions (local anesthetic poisoning, hypotension, decreased heart rate, etc.);The total amount of analgesic drugs required by the patient during the operation;Patients were admitted to the resuscitation room for scoring;Adverse reactions and complications;After the pain gets worse, the patient needs to be given extra time and dose of analgesic drugs (fixed drugs) in the ward.;The time of the patient's first out-of-bed activity and the time of the patient's anal exhaust; | — |
Countries
China
Contacts
Public ContactJiang Zhu
The Second Affiliated Hospital of Soochow University
Outcome results
None listed