Uterine disease
Conditions
Interventions
Group C:Intravenous saline before induction of anesthesia
Group P (P1, P2, P3, P4, P5):Different doses of nalbuphine before induction
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged >= 45 years; 2. Patients who need laparoscopic hysterectomy; 3. ASA I-II; 4. Patients weighing 50-70kg; 5. Patients who do not use analgesia pump after operation; 6. Patients who sign informed consent and are willing to be followed up.
Exclusion criteria
Exclusion criteria: 1. People who are allergic to naborphine; 2. With history of chronic pain; 3. With history of opioid addiction; 4. Inability to assess pain properly; 5. With application of non-steroidal anti-inflammatory drugs before surgery; 6. There are important organ diseases such as liver and kidney; 7. Have respiratory, circulatory and endocrine system diseases; 8. Patients who are participating in other experiments.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| NRS score;VAS score at various time points after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Hemodynamic indicators at various time points during the operation;Cough score during extubation;Sedation score 10 minutes after extubation;Incidence of adverse reactions within 24 hours after surgery; | — |
Countries
China
Contacts
Public ContactQi Dunyi
Department of Anesthesiology, Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed