traumatic brain injury
Conditions
Interventions
Sponsors
Department of Neurosurgery, The first medical center of the Chinese PLA General Hospital
Eligibility
Sex/Gender
Male
Age
15 Years to 65 Years
Inclusion criteria
Inclusion criteria: Acute TBI patients admitted within 8 hours of injury were enrolled in the study. They were diagnosed with acute moderate to severe TBI(Glasgow Coma Scale score on admission was 3 to 12)and without other important organs were injured .Intracranial brain contusion and laceration confirmed by head Computed tomography (CT)hematoma intracranial hematoma epidural or subdural hematoma and other clear organic lesions. Patients were included if they were between15 and 65 years of age, required emergency craniotomy and were operated on within 12 hours of injury.
Exclusion criteria
Exclusion criteria: The exclusion criteria included severe multiple or combined injury patients, history of severe chronic illness,Participants in any other drug trial 1 month prior to the trial and during the trial period,had malignant tumor and other diseases of the nervous system and immune system,pregnant and lactating women,patients with blood transfusion of more than 400ml during treatment,Uncooperative, automatic discharge or death patients, patients who need a second craniotomy due to changes in their condition and any history of allergy to YNBY capsules.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Glasgow Coma Scale, GCS;Glasgow Outcome Scale, GOS;Karnofsky Performance Scale, KPS;S100B;Superoxide Dismutase SOD; | — |
Countries
China
Contacts
Public ContactXiao-dong Ma
Department of Neurosurgery, The first medical center of the Chinese PLA General Hospital
Outcome results
None listed