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Clinical study for chronic anterior cruciate ligament reconstruction combined with platelet-rich plasma (PRP) intra-articular injection on chronic anterior cruciate ligament deficient knee with osteoarthritis

Clinical study for chronic anterior cruciate ligament reconstruction combined with platelet-rich plasma (PRP) intra-articular injection on chronic anterior cruciate ligament deficient knee with osteoarthritis

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000030271
Enrollment
Unknown
Registered
2020-02-27
Start date
2020-04-01
Completion date
Unknown
Last updated
2020-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronic anterior cruciate ligament injury

Interventions

ACLR+PRP:PRP injection
ACLR:Without PRP injection

Sponsors

Shenzhen Second People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1. Chronic ACL injury (injury time is more than 1 year); 2. Preoperative imaging data confirmed that ACL was broken or tension footprints disappeared; 3. The Kellgren Lawrence grade of knee osteoarthritis 1-3; 4. ACL reconstruction under arthroscopy for the first time; 5. aged 18-50 years.

Exclusion criteria

Exclusion criteria: 1. Acute or subacute ACL injury or multiple ligament injury; 2. Knee joint with fracture, tumor or previous operation history or other knee joint diseases such as rheumatoid Arthritis or postoperative recurrent swelling, infection; 3. Patients with serious basic diseases such as hypertension, coronary heart disease, diabetes, severe damage of liver and kidney function, etc; 4. Pregnant women; patients who may need to be pregnant during the trial.

Design outcomes

Primary

MeasureTime frame
IKDC2000 score;Lysholm score;MRI T2 mapping of ACL;second look of arthroscopy surgery;

Countries

China

Contacts

Public ContactZhong Mingjin

Shenzhen Second People's Hospital

sportsmedzhong@sina.com+86 13602655067

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026