Application of Improved PEEP Based on Pressure-Volume Curve in Perioperative Mechanical Ventilation of COPD Patients

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000030202

Enrollment

Unknown

Registered

2020-02-25

Start date

2020-03-01

Completion date

Unknown

Last updated

2020-03-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Anesthesiology

Interventions

PCV1:Conventional mechanical ventilation, using fresh air flow 2L / min, VT 8ml / kg, FiO2 60%, RR 12 times / min, breathing ratio 1: 2, adjust the breathing frequency as appropriate to maintain PaCO2

PCV2:During the operation, a ventilation strategy with a small tidal volume of VT 6ml / kg and PEEP 6cm H2O was used. The other ventilation strategy was the same as the PV1 group.

PLIP+2:Take the pressure value corresponding to the inflection point under the P-V curve of the inspiratory phase displayed by the Drager Infinity Deltaxl monitor after 10 minutes of conventional mech

Eligibility

Sex/Gender

All

Age

18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. 90 patients with stable COPD who need general anesthesia with endotracheal intubation and mechanical ventilation. 2. The ASA classification is I to II, both men and women.

Exclusion criteria

Exclusion criteria: 1. Patients who were allergic to narcotics; 2. With abnormal blood coagulation function; 3. With severe cardiovascular disease (severe valvular disease, left ventricular ejection fraction = III, coronary heart disease, myocardial infarction, etc.)with lung diseases other than COPD (pulmonary fibrosis, lung infections, etc.); 4. With neurological disease (history of stroke, cerebrovascular embolism, etc.); 5. With liver and kidney dysfunction;with a mental illness; 6. Who need surgery again due to changes in disease.

Design outcomes

Primary

Measure	Time frame
Respiratory parameters related to mechanical ventilation: peak airway pressure (Ppeak), airway plateau pressure (Ppalt), dynamic lung compliance (Cdyn), and airway resistance (Raw);;arterial blood gas analysis;Postoperative pulmonary complications;	—

Secondary

Measure	Time frame
Plasma IL-6 and IL-8 levels;Cerebral oxygen saturation;	—

Countries

China

Contacts

Public ContactJian Guo

The Fourth Affiliated Hospital of Zhejiang University Medical College

guo86jian@zju.edu.cn+86 13858116560

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026