Healthy volunteers, population at high risk of lung cancer, pulmonary nodules
Conditions
Interventions
Intervention group:Lemon powder
Control group:Placebo
Sponsors
Tongren Hospital, Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Stage A: 1. Healthy subjects aged >=18 years; 2. BMI > 18.5kg / m2; 3. No history of allergies to citrus fruits; 4. Voluntarily participate and sign the informed consent; Stage B additonally includes the following criteria: 1. 6 months or more in BBQ service and at least 4 days a week in the workplace. Stage C additionally includes the following inclusion criteria: 1. Aged >= 40 years. 2. Meet the diagnostic criteria of small pulmonary nodules, with a diameter of 10 mm or less.
Exclusion criteria
Exclusion criteria: 1. Patients with acute or chronic gastrointestinal diseases, including acute gastritis, chronic gastritis, peptic ulcer, acute enteritis, chronic enteritis, irritable bowel syndrome, etc. 2. Consumed more than 500g/d of citrus food in the past week (fruit juice, lemon, citrus peel, grapefruit tea, etc). 3. Complicated with serious diseases such as heart, liver, kidney or hematopoietic system. 4. Pregnant or breast-feeding women, women of child-bearing potential who do not use adequate contraception. 6. Taking anti-inflammatory drugs or antioxidant supplements (such as vitamin C or vitamin E). 7. Those with surgery arrangements in the next 3 months. 8. Participated in another clinical trial within the past 3 months. 9. There are other serious diseases that researchers consider unsuitable to participate in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intervention implementation compliance rate (Stage A);Urine S-phenylthioglycolic acid (SPMA) level (Stage B);Serum miR-195 expression level (Stage C); | — |
Secondary
| Measure | Time frame |
|---|---|
| Inflammation markers;Metabolites;Pulmonary function;Control rate of pulmonary nodules;Oxidative stress markers;Urinary metabolomics;Safety indicators; | — |
Countries
China
Contacts
Public ContactBiyun Qian
Tongren Hospital, Shanghai Jiaotong University School of Medicine
Outcome results
None listed