A randomized controlled study of imiquimod combined with CO2 laser in the treatment of vaginal intraepithelial neoplasia

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000030180

Enrollment

Unknown

Registered

2020-02-24

Start date

2020-05-01

Completion date

Unknown

Last updated

2020-02-25

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Vaginal intraepithelial neoplasia

Interventions

experimental group:primary CO2 laser treatment combined with imiquimod maintenance treatment

control group:CO2 laser repeat treatment

Eligibility

Sex/Gender

Female

Age

18 Years to 65 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-65 years; 2. VaIN diagnosed by colposcopy.

Exclusion criteria

Exclusion criteria: 1. Active genital infection and incomplete vaginal mucosa; 2. After radiotherapy for invasive cervical or vaginal cancer; 3. Invasive vaginal cancer; 4. Severe heart disease, liver and kidney disease, diabetes, blood disease and nervous system disease.

Design outcomes

Primary

Measure	Time frame
VaIN Lesion clearance rate;HPV clearance rate;	—

Countries

China

Contacts

Public ContactChu Lei

Shanghai Tongji hospital

chulei1982@yeah.net+86 13764427321

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026