Cervical Carcinoma
Conditions
Interventions
control group:Abdominal radical hysterectomy and pelvic lymph node dissection, with or without abdominal aortic lymph node resection
experimental group:Laparoscopic radical hysterectomy and pelvic lymph node dissection, with or without abdominal aortic lymph node resection
Sponsors
Cancer Hospital of University of Chinese Academy of Sciences
Eligibility
Sex/Gender
Female
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years; 2. FIGO(2018) stage is IA1 (with blood vessel invasion), IA2 and IB1; 3. the maximum diameter of the tumor 3.0x10^9cells/L; (2) Platelet count > 100x10^9/L; (3) Creatinine < 180 umol/L; (4) Bilirubin < 1.5 times normal, and AST/ALT< 3 times normal; 9. ECOG score 0-1; 10. patients with surgical indications; 11. patients who have signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. the imaging assessment showed that the cervical tumor invaded the outer third of the interstitial layer, or involved the lower part of the uterus. 2. serum levels of AFP, HCG were elevated, or CEA, CA199 and CA125 were more than 5 times higher than normal. 3. pregnant women; 4. patients with surgical contraindications; 5. patients with metastatic lesions, pelvic/abdominal para-aortic lymph node enlargement (> 2cm, or minor axis > 1cm, or patients with positive lymph nodes; 6. patients who accompanied by serious systemic diseases inconsistent with the study (at the discretion of the investigator); 7. patients who cannot tolerate bladder lithotomy or trendelenburg position; 8. patients whose medical compliance and geographical location cannot guarantee adequate follow-up; 9. patients with a history of pelvic or peritoneal radiotherapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| disease free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| recurrence pattern and site of the two groups;Incidence of treatment-related complications within 6 months after surgery of the two groups;economic cost-effectiveness of both groups;quality of life for both groups;pelvic floor function in both groups;overall survival; | — |
Countries
China
Contacts
Public ContactTao Zhu
Cancer Hospital of University of Chinese Academy of Sciences
Outcome results
None listed