Novel Coronavirus Pneumonia (COVID-19)
Conditions
Interventions
Experimental group:High-dose Vitamin C
Control group:Routine treatment
Sponsors
The Second Affiliated Hospital Of Xi'an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Aged>=18 years old; 2. Diagnosed as severe and critical patients with novel coronavirus pneumonia; 3. Being treated in the ICU.
Exclusion criteria
Exclusion criteria: 1. Allergic to vitamin C; 2. Cardiogenic dyspnea; 3. Life expectancy<24h; 4. Pregnant and/or lactating female; 5. There is a state of tracheotomy or home oxygen therapy in the past; 6. Previously complicated with interstitial lung disease, malignant tumors,diffuse alveolar hemorrhage, diabetic ketoacidosis, or an active kidney stone; 7. Participating in other clinical trials; 8. Researchers believe patients are not suitable for clinical trials for other reasons.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ventilation-free days;mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| ICU length of stay;Chest CT;Routine blood test;C-reactive protein;Liver and renal function ;APACHE II scores;SOFA scores;Myocardial markers;Electrocardiogram;Adverse events; | — |
Countries
China
Contacts
Public ContactGao Dengfeng
The Second Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed