Gastrointestinal disease
Conditions
Interventions
Low concentration group:Sevoflurane concentration0.7MAC-0.9MAC
Medium concentration group:Sevoflurane concentration0.9MAC-1.1MAC
High concentration group:Sevoflurane concentration1.1MAC-1.3MAC
Simple intravenous group :propofol2-4mg/kg/h
Sponsors
The First Affiliated Hospital of Anhui Medical University
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Sign informed consent; 2. Aged >= 65 years; 3. ASA grade I - III; 4. Patients who plan to undergo major abdominal surgery (operation time> 1.5hours).
Exclusion criteria
Exclusion criteria: 1. Patients with dementia or severe cognitive dysfunction unstable mental state or concomitant mental illness; 2. Those who receive psychotherapy and abuse narcotic sedative and analgesic drugs; 3. Preoperative diagnosis of delirium or previous history of delirium; 4. Patients who have received anesthesia or operation in the past 6 months; 5. Patients who have any factors affecting cognitive assessment such as severe infections of speech, visual and hearing disorders; 6. Patients who need to undergo surgery again within 5 days after operation; 7. Any cerebrovascular accident such as stroke within 3 months, Transient ischemic attack (TIA), etc.; 8. Those who are contraindicated in the use of sevoflurane.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative delirium; | — |
Countries
China
Contacts
Public ContactXuesheng Liu
The First Affiliated Hospital of Anhui Medical University
Outcome results
None listed