Sepsis
Conditions
Interventions
Control:dobutamine
Intervention:levosimendan
Sponsors
Zhejiang Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. The diagnosis of septic shock conforms to the Chinese guidelines for the treatment of severe sepsis / septic shock (2014); 2. Echocardiography showed that the left ventricular ejection fraction (LVEF) was less than 50%; 3. Candidates are required to sign informed consent.
Exclusion criteria
Exclusion criteria: 1. End stage renal failure (dependent on hemofiltration); 2. Severe chronic liver insufficiency; 3. Patients with a history of torsion at the tip; 4. Restrict the use of positive inotropic drugs (such as left ventricular outflow tract stenosis); 5. the use of levosimendan treatment within 30 days; 6. Acute myocardial infarction; 7. Patients with a history of chronic heart failure; 8. After cardiac surgery; 9. malignant arrhythmia; 10. Pericardial disease; 11. The patient does not want to be treated by levosimendan.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 28-day mortality; | — |
Secondary
| Measure | Time frame |
|---|---|
| OlO].The time of mechanical ventilation;Lactate;Length of stay in ICU;Cardiac Function;Liver and kidney function; | — |
Countries
China
Contacts
Public ContactLi Li
Department of Intensive Care Medicine, Zhejiang Hospital
Outcome results
None listed