Functional constipation
Conditions
Interventions
Sponsors
China-Japan Friendship Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-70 years; 2. Meet the Rome IV diagnostic criteria for functional constipation; 3. The stool type is Bristol1, 2 type; 4. Voluntarily participate in this topic and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Pregnant women,or women preparing for pregnancy or breastfeeding; 2. Severe heart, brain, and kidney disease, generally poor condition or organ failure; 3. Patients who have been taking drugs that affect constipation for a long time, such as diabetes, hypothyroidism, electrolyte disturbance, and scleroderma; 4. Drugs that cannot affect the gastrointestinal motility / sensory function in the test: such as gastric motility drugs, erythromycin antibiotics, anticholinergics, anesthetic pain agents, antidepressants, calcium channel blockers, diuretics, calcium Agents, iron agents, antidiarrheals, antihistamines, etc.; 5. Took antibiotics or microecological preparations in the last 2 weeks; 6. In the past 6 months, colonoscopy revealed organic intestinal diseases such as intestinal tuberculosis, intestinal obstruction, intestinal tumors, intestinal diverticulum, congenital megacolon, and colonic prolongation (colon polyps <= 3 and Benign lesions with a maximum polyp diameter <= 0.5 cm can be included); 7. With constipation of irritable bowel syndrome. 8. Patients after hysterectomy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| plete voluntary defecation frequency per week; | — |
Secondary
| Measure | Time frame |
|---|---|
| gastrointestinal transit time;high resolution anorectal manometry;constipation-related symptom rating scale;Determination of fecal short-chain fatty acids;Traditional Chinese Medicine syndrome score scale; | — |
Countries
China
Contacts
Public ContactYao Shukun
China-Japan Friendship Hospital
Outcome results
None listed