primary hepatocellular carcinoma
Conditions
Interventions
experimental group:Callispheres carrier drug microsphere
control group:traditional iodide oil embolization (cTACE)
Sponsors
The First Affiliated Hospital of University of Science and Technology of China
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients with primary hepatocellular carcinoma confirmed clinically or pathologically; (2) Aged 18-80 years, with an expected survival period of >= 3 months; (3) The number of tumors is 5 cm; or 2-3, at least one> 3 cm); (4) Child-Pugh grade A or B for liver function; ECOG performance status score = 3.0 x 10^9 / L; platelet count >= 50 x 10^9 / L; (7) The international normalized ratio (INR) of prothrombin time <= 2.3 or prolonged prothrombin time (PT) <=3 seconds; (8) Serum creatinine is less than 1.5 times the upper limit of normal; (9) Patients and / or family members agree to participate in clinical trials and sign informed consent.
Exclusion criteria
Exclusion criteria: (1) Diffuse liver cancer; (2) Bile duct cell carcinoma; (3) Patients with grade III-IV portal vein tumor thrombus; (4) Patients who have undergone ablation surgery; (5) The tumor volume is too large, such as more than 2/3 of the liver volume; (6) Uncorrectable coagulation dysfunction, who have obvious bleeding tendency; (7) Severe liver cirrhosis, ascites above moderate amount; (8) Serious heart, lung, kidney and other important organ diseases and dysfunction; (9) Uncontrolled infections such as HIV, sepsis, biliary infections, liver abscesses or other active infections; (10) Pregnant and lactating women; (11) History of organ transplantation; (12) CT / MRI cannot be performed; (13) Subjects participating in other clinical trials at the same time.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| MRI or CT of the liver;AFP;blood routine;liver function;ECOG score; | — |
Countries
China
Contacts
Public ContactLv Weifu
The First Affiliated Hospital of University of Science and Technology of China
Outcome results
None listed