Novel Coronavirus Pneumonia (COVID-19)
Conditions
Interventions
Case series:Suramin( IV.)
Sponsors
The First Affiliated Hospital of Zhejiang University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18 to 75 years male or female, willing to sign the informed consent; 2. Patients with novel coronavirus infection pneumonia were confirmed by epidemiology and clinical symptoms. The diagnostic criteria refer to "Pneumonitis Diagnosis and Treatment Scheme for Novel Coronavirus Infection (Trial Version 6)"; 3.Tested positive for novel coronavirus infection using a real time polymerase chain reaction (RT-PCR)-based diagnostic assay; or highly homologous to COVID-19 according to Virus gene sequencing; 4. Patients with pneumonia were confirmed by Chest imaging; 5. Enrollment and initiation of study drug treatment <=10 days after onset of symptoms; Symptom are mainly fever, or cough on patients without fever; 6. Willing to abide by the protocol according investigators.
Exclusion criteria
Exclusion criteria: 1. Hypersensitive to suramin or 2 or more drugs or food; 2. Body weight <40 kg; 3. Considered as severe disease: has an ongoing respiratory deficiency and subjected to invasive mechanical ventilation; or presence of shock; or admitted to the ICU due to complications; 4. Has known kidney dysfunction determined as CLcr<60 mL/min; 5. Increase in alanine aminotransferase (ALT) / aspartate aminotransferase (AST) is more than 5 times the upper limit of normal; or increase in ALT or AST is more than 3 ULN and increase in total bilirubin more than 2 ULN; 6. Pregnancy or breastfeeding, or positive pregnancy test in a predose examination, or have a plan to be pregnant within 3 months after the study; 7. Physician judged the patient was not suitable for this clinical trial (for example, patient with severe abnormality laboratory indexes; patient with multiple basic diseases, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| clinical cure rate;Incidence of mechanical ventilation by day28;All-cause mortality by day28;Incidence of ICU admission by day28; | — |
Countries
China
Contacts
Public ContactShentu Jianzhong?Wu Lihua
The First Affiliated Hospital of Zhejiang University School of Medicine
Outcome results
None listed