liver carcinoma
Conditions
Interventions
Intravenous analgesia group:intravenous patient-controlled analgesia
Erect spinae plane block group:patient-controlled analgesia with erect spinae plane block
Sponsors
Zhongshan Hospital Affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients with open liver resection due to hepatocellular liver cancer; (2) Patients with preoperative coagulation function abnormalities: international standardized ratio (INR) s >= 1.4, platelet count 38s; (3) The anesthesiologist has concerns about the coagulation function and considers it inappropriate to do epidural punctures; (4) Patients have sufficient language communication ability to complete postoperative follow-up; (5) Patients are voluntary and sign informed consent.
Exclusion criteria
Exclusion criteria: (1) Aged 80 years; (2) History of local anesthetic allergy; (3) Long-term opioid analgesia due to chronic pain; (4) Joint surgery (except gallbladder resection); (5) Pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The average resting NRS score for all follow-up points, including the day of surgery and postoperative 3 days.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Average daily NRS score for postoperative 3 days (rest/cough);Total daily retrieve medication dosage for postoperative 3 days;Adverse effects related to analgesia of postoperative 3 days (itching, nausea and vomiting, urinary retention);Incidence of low blood pressure associated with analgesia within postoperative 3 days;Patient satisfaction with pain management;Incidence of acute kidney injury(AKI): AKI diagnosed according to the AKIN acute kidney injury diagnostic criteria;Incidence of postoperative complications to varying degrees: determined by the Accordion grading system of surgical complications;Changes in postoperative cellular immune function: draw peripheral blood (approximately 3 ml) to detect the activity percentage of T-cell subgroup CD3+, CD4+, CD8+T lymphocytes and NK cells (CD3 -/CD16+CD56+) at preoperative, 24h postoperative and 72h postoperative;Changes in coagulation function postoperatively: draw peripheral blood to detect the patient's coagulation function at preoperative, postoperative 24h, 72h;The liver tumor development;The time between the operation day and the time to meet the discharge criteria which is determined by the attending physician;Anesthesia costs, total costs during hospitalization;Mortality rate of the postoperative 30-day; | — |
Countries
China
Contacts
Public ContactZhang Xiaoguang
Outcome results
None listed