Novel Coronavirus Pneumonia (COVID-19)
Conditions
Interventions
Control group:No
Sponsors
Zhongnan Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) Male and female, 18-70 years old; 2) Severe patients (in any case: respiratory distress, RR >= 30 times / min; in resting state, oxygen saturation <= 93%; PaO2 / FiO2 <= 300MMHG); 3) Within 12 days after illness onset; 4) Agree to sign the informed consent; 5) Able to ingest, absorb and tolerate oral medication; 6) Agree to collect clinical samples; 7) Consent to contraceptive measures for sex within 7 days of the last oral medication.
Exclusion criteria
Exclusion criteria: 1) Cases with severe vomiting and difficulty in taking drugs orally or causing difficulty in taking drugs after oral administration; 2) Pregnant and lactating women; 3) The subjects received specific antiviral drugs such as lopinavir / lidonavir, ribavirin and monoclonal antibody within one week before admission; 4) Cases with no hope of survival, hospice care only, or deep coma and no response to supportive treatment within three hours after admission; 5) Cases of deep shock and respiratory failure; 6) Severe liver diseases (such as child Pugh score >= C, AST more than 5 times of the upper limit of normal); 7) Patients with severe renal insufficiency (estimated glomerular filtration rate <= 30ml / min / 1.73m2) or undergoing continuous renal replacement therapy, hemodialysis, peritoneal dialysis; 8) Patients with known allergic reactions or contraindications to chloroquine phosphate; 9) The doctor decided that it was not in the best interests of the subjects to participate in the study, or there was any situation in which the agreement could not be followed safely.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to Clinical Recovery; | — |
Secondary
| Measure | Time frame |
|---|---|
| All cause mortality;Length-of-stay in hospital;Length-of-stay in ICU;Days of mechanical ventilation;Modified BAP-65 and DECAF score; | — |
Countries
China
Contacts
Public ContactZhao Yan
Zhongnan Hospital of Wuhan University
Outcome results
None listed