Narcolepsy
Conditions
Interventions
narcolepsy with cataplexy group:take 18mg methylphenidate hydrochloride controlled-release tablets
Sponsors
Peking University People's Hospital
Eligibility
Sex/Gender
All
Age
5 Years to 17 Years
Inclusion criteria
Inclusion criteria: 1. Patients met the diagnostic criteria for NC based on the third edition of the International Classification of Sleep Disorders criteria1 4, with irrepressible sleepiness for more than three months associated with cataplexy and abnormal MSLT (mean sleep latency <=8 minutes and more than two sleep onset REM periods ) according to standard techniques; 2. Aged 4 to 18 years; 3. patients were drug naive before enrolling this study; 4. Signed and dated informed consent. Willingness and ability to comply with scheduled visits, treatment plans, laboratory tests, and other study procedure by patients with parent(s).
Exclusion criteria
Exclusion criteria: 1. comorbidity with other disorders that could affect BP or HR such as renal, cardiac, endocrine diseases; 2. taking any medicine that affects BP or sleep; 3. the presence of neurological psychiatric disorders; 4. have any behavior that may influence BP such as smoking, alcohol consumption; 5. contraindication for methylphenidate medication (e.g. glaucoma).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the values of ambulatory monitoring of blood pressure and heart rate;the values of mesor and amplitude of Blood pressure and heart rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| the rate of dipping; | — |
Countries
China
Contacts
Public ContactFang Han
Peking University People's Hospital
Outcome results
None listed