Chronic hepatitis B, Nonalcoholic fatty liver disease
Conditions
Interventions
Gold Standard:Liver histopathology
Index test:ElastQ
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 years; 2. CHB: Those who had a history of hepatitis B or had positive HBsAg for more than 6 months, but still had positive HBsAg and/or HBV-DNA. 3. NAFLD: (1) Imaging evidence of diffuse hepatocellular fatty change; (2) No history of excessive drinking (less than 30 g/d for men and less than 20 g/d for women); (3) Except alcoholic liver disease (ALD), genotype 3 HCV infection, autoimmune hepatitis, liver bean-like nuclear degeneration, etc, excluding drugs (hemoxifen, amine iodedone, sodium acetate, methotrexate, glucocorticoids, etc.), whole gastrointestinal nutrition, inflammatory bowel disease, celiac, hypothyroidism, Cushing syndrome, beta lipoprotein deficiency emias, lipid atrophy diabetes, Mauriac syndrome, etc.; (4) No specific symptoms and signs, patients can appear serum ALT and GGT increase.
Exclusion criteria
Exclusion criteria: (1) Patients received liver transplantation (2) Pregnant or lactating women (3) Patients with severe pulmonary insufficiency and respiratory incompatibility (4) Patients with obesity (BMI > 30kg/m2, male abdominal circumference > 90cm, female abdominal circumference > 90cm) and difficulty in penetrating elastic shear wave (5) Complicated with other liver diseases such as hepatic vein embolism, intrahepatic bile duct dilatation or biliary obstruction (6) Patients with unstable clinical state, advanced disease or unpredictable clinical course (7) Patient without pathological diagnosis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| sensitivity;specificity;ACC;AUC of ROC; | — |
Countries
China
Contacts
Public ContactLuo Yan
Department of Ultrasound, West China Hospital, Sichuan University
Outcome results
None listed