Gastrointestinal stromal tumor
Conditions
Interventions
One:Surgery + Imatinib400mg/d
Two:imatinib 600mg/d or sunitinib 37.5mg/d
Sponsors
Zhongshan Hospital affiliated to Fudan University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patients with recurrent/metastatic GIST were clearly diagnosed by pathology and had undergone standardized IM treatment, during which the disease progressed; 2. Progressive lesions are limited to one organ and the number is <=3; After evaluation by the relevant surgical experts or MDT discussion, it was considered that the progressive lesion could be safely removed completely without significant influence on organ function. 3. Aged 18-75 years; 4. No other malignant tumors occurred within five years; 5. ECOG physical status score of patients <2, ASA score <3; 6. There are no restrictions on gender or race; 7. Informed consent of patients.
Exclusion criteria
Exclusion criteria: 1. There are other serious complications, the patient can not tolerate surgery, such as with severe lung disease, cardiac function in clinical grading below level 2, pulmonary infection, moderately severe COPD, chronic bronchitis, etc, severe diabetes and/or renal dysfunction, and severe hepatitis and/or functional Child - pugh, class C and symptoms is difficult to correct(class B), and severe malnutrition, etc; 2. Patients with IM primary drug resistance; 3. Bleeding, perforation, obstruction and other disease-related complications, requiring emergency surgery; 4. Pregnant or nursing women; 5. The patients suffer from serious mental illness; 6. Patients with other malignant tumors within five years; 7. The patients have participated in or are participating in other clinical studies, or are using other TKI preparations;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| One year progression-free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| one year overall survival;Incidence of adverse events;quality of life; | — |
Countries
China
Contacts
Public ContactShen Kuntang
Zhongshan hospital affiliated to Fudan university
Outcome results
None listed