Postoperative pain
Conditions
Interventions
Multimodal analgesia group:Transversus abdominis plane block combined with paracetamol and non-steroidal anti-inflammatory drugs
Traditional analgesia group:Intravenous opioid analgesia
Sponsors
Department of Anesthesiology, Beijing University First Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-65 years, ASA I-II; 2. Patients with endometrial, ovarian or cervical cancer who will undertake elective laparotomy under general anesthesia; 3. Sign informed consent.
Exclusion criteria
Exclusion criteria: 1. Bowel resection is expected during operation 2. Abnormal coagulation function; 3. BMI > 40kg / m2; 4. Skin infection at puncture site of abdominal nerve block; 5. History of Severe hypertension, diabetes mellitus, ischemic heart disease, heart failure and stroke; 6. History of peptic ulcer, bleeding or perforation; 7. Severe hepatorenal insufficiency (creatinine clearance rate 7 points); 8. Allergic history of ropivacaine, paracetamol, NSAID and floxacin; 9. Long term medication history of opioids, monoamine oxidase inhibitors, dicoumarin anticoagulants, selective 5-hydroxytryptamine reuptake inhibitors, or NSAID analgesics; 10. Alcohol addiction or drug abuse before surgery; 11. Unable to understand pain score or verbal communication disorder; 12. Pregnant or lactating patients; 13. Patients who have participated in other clinical studies.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Morphine dosage in 24h after surgery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative analgesia score;Operation of analgesia pump;Dosage of supplementary analgesics;Analgesia satisfaction;Analgesic side effects;Postoperative rehabilitation;Expense during hospital stay;Postoperative 30-day complications;Postoperative 30-day quality of life; | — |
Countries
China
Contacts
Public ContactGeng Zhiyu
Department of anesthesiology, Beijing University First Hospital
Outcome results
None listed