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A multicenter registration study for the correlation of NfL and neurological deterioration in ischemic stroke and the role of butylphthalide in its prevention

A multicenter registration study for the correlation of NfL and neurological deterioration in ischemic stroke and the role of butylphthalide in its prevention

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000029902
Enrollment
Unknown
Registered
2020-02-16
Start date
2020-03-01
Completion date
Unknown
Last updated
2020-02-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ischemic stroke

Interventions

experimental group:standard therapies based on guideline and NBP
control group:standard therapies based on guideline

Sponsors

Deyang People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Symptoms of neurological deficit caused by ischemic stroke; 2. Age from 18 years to 80 years; 3. Patients with a National Institutes of Health Stroke Scale (NIHSS) score from 1 to 10 points; 4. From the onset of stroke symptoms to the intended treatment <= 48 hours;(for wakeup stroke patients, define the onset time as when the patient starts to fall asleep); 5. The symtoms lasts for at least 30 minutes without significant improvement or deterioration before treatment; 6. Patients who provided consent to participate in this study.

Exclusion criteria

Exclusion criteria: 1. Patients with a Modified Rankin Scale (MRS) score >= 2 points before stroke; 2. Transient ischemic attack (TIA); 3. Patients receiving endovascular thrombectomy; 4. Patients with severe liver and kidney dysfunction, cardiac dysfunction, peripheral blood disease, or other severe systemic diseases, etc.; 5. Intracranial hemorrhagic diseases seen on CT / MRI: cerebral hemorrhage, subarachnoid hemorrhage, etc., or diseases with a bleeding tendency; 6. Patients with concurrent malignant tumors or undergoing anti-tumor treatment; 7. People with a history of allergies to celery or NBI; 8. Patients who are pregnant, breastfeeding, or have a chance of becoming pregnant, and who plan to become pregnant; 9. Participated in other interventional clinical studies within 3 months or is participating in other interventional clinical studies; 10. Blood glucose level 22.2 mmol / L; 11. Patients that the investigator considers inappropriate for this clinical study.

Design outcomes

Primary

MeasureTime frame
END;

Countries

China

Contacts

Public ContactLi Jie

Deyang People's Hospital

1151586627@qq.com+86 838-2418251

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026