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The effect of berberine hydrochloride on apolipoprotein A1, serum inflammatory factors, carotid atherosclerosis and clinical prognosis of patients with stroke

The effect of berberine hydrochloride on carotid atherosclerosis, middle cerebral artery stenosis and homocysteine in patients with stroke

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000029838
Enrollment
Unknown
Registered
2020-02-15
Start date
2018-06-01
Completion date
Unknown
Last updated
2020-02-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Carotid Atherosclerosis,Middle Cerebral Artery Stenosis, Homocysteine

Interventions

Hypertension with Homocysteine:extended release nifedipine tablets+Vitamin B6+Vitamin B12+folic acid/berberine/berberine+folic acid
Middle Cerebral Artery Stenosis:Atorvastatin+Aspirin/Aspirin+berberine
Carotid atherosclerosis:Atorvastatin+Aspirin/Aspirin+berberine

Sponsors

The First Central Hospital of Baoding
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: (1) Patients aged 18-80 years; (2) Patients agree and sign an informed consent.

Exclusion criteria

Exclusion criteria: (1) The allergic and other server adverse reactions to drugs in the treatment; (2) Complication severe infection or critical illness; (3) Severe complications including cancer, cardiopulmonary insufficiency, impaired liver function, kidney injury, or other immune diseases; (4) Consistent with the indications of thrombolysis or surgery; (5) Patients could not follow the program or incomplete clinical data.

Design outcomes

Primary

MeasureTime frame
Homocysteine;Middle Cerebral Artery Stenosis;Carotid plaque;Analysis of intestinal flora gene chip;

Secondary

MeasureTime frame
Blood glucose, triglyceride, total cholesterol, low density lipoprotein;

Countries

China

Contacts

Public ContactPei Wang

The First Central Hospital of Baoding

w_z_h_01@163.com+86 18617789057

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026