The adjunctive use of (-)-epigallocatechin gallate (EGCG) subgingival irrigating solution with scaling and root planing in the management of chronic periodontitis

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2000029831

Enrollment

Unknown

Registered

2020-02-15

Start date

2018-01-01

Completion date

Unknown

Last updated

2020-02-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Chronic periodontitis

Interventions

Supragingival medication group:Ultrasonic scaling and root planing with EGCG aqueous solution and traditional scaling tips

Supragingival control group:Ultrasonic scaling and root planing with distilled water and traditional scaling tips

Subgingival medication group:Ultrasonic scaling and root planing with EGCG aqueous solution and new-type scaling tips

Subgingival control group:Ultrasonic scaling and root planing with distilled water and new-type scaling tips

Ultrasonic irrigation group:After scaling and root planing, ultrasonic irrigating with EGCG aqueous solution

Normal irrigation group:After scaling and root planing, normal irrigating with EGCG aqueous solution

Eligibility

Sex/Gender

All

Age

28 Years to 57 Years

Inclusion criteria

Inclusion criteria: (1) Patients having chronic periodontitis; (2) At least two teeth having PD 5-8 mm each posterior segment; (3) More than 10 teeth in the maxillary dentition, except for wisdom teeth.

Exclusion criteria

Exclusion criteria: (1) Smokers; (2) Pregnant or lactating mothers; (3) Patients having systemic diseases; (4) Patients having oral diseases like severe infections, tumors and mucosal disease; (5) Patients who have received any topical or systemic antimicrobial treatment in the past 6 months; (6) Patients who had periodontal treatment in the past 6 months.

Design outcomes

Primary

Measure	Time frame
Pocket probing depth, PPD;Clinical attachment level, CAL;	—

Secondary

Measure	Time frame
Bleeding index, BI;Gingival index, GI;Plaque index, PLI;	—

Countries

China

Contacts

Public ContactQINGXIAN LUAN

School of Stomatology, Peking University

kqluanqx@126.com+86 13651330496

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 16, 2026