Post-Stroke Depression
Conditions
Interventions
Group A:Active tDCS/Placebo pill
Group B:Sham tDCS/escitaplopram
Group C:Sham tDCS/Placebo pill
Sponsors
Shanghai Seventh People's Hospital, Shanghai University of TCM
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Between 18 and 75 years of age with no gender-based restriction; 2. First or recurrent ischemic stroke that was confirmed by brain CT or MRI; 3. A minimum of 3 months and a maximum of 5-years post-stroke; 4. The Diagnostic and Statistical Manual of Mental Disorders version 5 (DSM-V) diagnosis for depression due to stroke 5. 17-item Hamilton Depression Rating Scale (HDRS-17) score greater than or equal to 17 points and less than 24 (24 > HDRS-17 >= 17); 6. Patients willing to participate in the RCT and sign informed consent forms; 7. Right-handedness.
Exclusion criteria
Exclusion criteria: 1. Individuals with any lifetime history of depression, anxiety, bipolar disorder, schizophrenia, etc. 2. Individuals with substance abuse, panic disorder, or post-traumatic stress disorder in the past 6 months prior to admission of stroke; 3. A high risk of attempting suicide (a score of more than 2 points on the third question (Suicide) of the HDRS-17) 4. Aphasia and severe cognitive impairment (MMSE scores<10 points). 5. Presence of other mental disorders (such as adaptation disorders) caused by substance abuse (such as medication, drug addiction, alcoholism) 6. Current or prior any psychological intervention for any reason. 7. Participation in another clinical trial 8. Currently Pregnant or breast-feeding
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HRSD, MMSE and MoCA scores; | — |
Secondary
| Measure | Time frame |
|---|---|
| Zung Self-Rating Depression Scale, Barthel index, mBDNF/proBDNF, IFN- ?/IL-10; | — |
Countries
China
Contacts
Public ContactZhenxiang Han
Shanghai Seventh People's Hospital, Shanghai University of TCM
Outcome results
None listed