Novel Coronavirus Pneumonia (COVID-19)
Conditions
Interventions
A1:Hydroxychloroquine, small dose
A2:Hydroxychloroquine, high dose
B1:Abidol hydrochloride, small dose
B2:Abidol hydrochloride, high dose
Sponsors
Renmin Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. 18 years old <= age <= 60 years old when screening, not limited to men and women; 2. Who are in close contact with suspected cases, confirmed cases, and positive test of new coronavirus nucleic acid, and those who have not taken effective protection, that is, close contacts; 3. Study subjects are willing to be randomly assigned to any designated treatment group; 4. Must agree to not participate in another study of study drugs until day 24 of completion of the study. 5. Participants volunteered to participate in this study and signed informed consent.
Exclusion criteria
Exclusion criteria: 1. The physician decides that participating in the trial is not in the best interest of the patient, or does not meet any conditions for safe follow-up in the protocol; 2. People with heart disease such as cardiac block; 3. People with eye diseases such as retina and cornea; 4. Severe liver disease (such as Child Pugh score >= C or AST > 5 times the upper limit); 5. Pregnancy or breastfeeding, or a positive pregnancy test during the pre-dose check; 6. Patients with known severe renal insufficiency (estimated glomerular filtration rate <= 30mL / min / 1.73m2) or receiving continuous renal replacement therapy, hemodialysis, peritoneal dialysis.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of patients who have progressed to suspected or confirmed within 24 days of exposure to new coronavirus; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical manifestations and severity of suspected or confirmed patients;Body temperature;Cough severity classification;Oxygenation index;Chest CT lesion size;Incidence of severe adverse drug reactions;Blood routine, CRP, SAA values; | — |
Countries
China
Contacts
Public ContactZhan Zhang
Renmin Hospital of Wuhan University
Outcome results
None listed