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Clinical effect and mechanism of high frequency transcranial magnetic stimulation in the treatment of nonalcoholic fatty liver disease

Clinical effect and mechanism of high frequency transcranial magnetic stimulation in the treatment of nonalcoholic fatty liver disease

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2000029785
Enrollment
Unknown
Registered
2020-02-13
Start date
2020-04-01
Completion date
Unknown
Last updated
2020-02-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Non-alcoholic fatty liver disease

Interventions

experimental group :rTMS

Sponsors

Affiliated Hospital of Hangzhou Normal University
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 50 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-50 years (including cut-off value), gender, ethnicity is not limited, right-handed. 2. Body mass index (BMI)> 28kg / m2. 3. Patients with NAFLD confirmed by MRI-PDFF before randomization. 4. Fasting blood glucose, glycated hemoglobin, fasting glucose / insulin ratio, blood routine, TSH and T4 are all within normal ranges. 5. No history or past history of drinking (long-term, continuous drinking >= 5) average female alcohol intake <10g / day, male average alcohol intake <20g / day.

Exclusion criteria

Exclusion criteria: 1. With history of epilepsy; 2. With history of head and eye injuries; 3. Metal implants, pacemakers, claustrophobia and any other contraindications to fMRI or rTMS in the body; 4. Using antipsychotics; 5. Taking other NAFLD medications; 6. People who are taking weight-loss drugs or recent low-calorie diets; 7. Pregnant and breastfeeding.

Design outcomes

Primary

MeasureTime frame
BMI;glutamic-pyruvic transaminase;glutamic oxalacetic transaminase;?-glutamine transferase;Triglyceride;Total cholesterol;High density lipoprotein;Low density lipoprotein;Leptin;

Countries

China

Contacts

Public ContactJunping Shi

Affiliated Hospital of Hangzhou Normal University

20131004@hznu.edu.cn+86 13957121199

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026