Elderly patients with acute myeloid leukemia/high risk myelodysplastic syndrome
Conditions
Interventions
Sponsors
The Second Affiliated Hospital of Dalian Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Patient with acute myeloid leukemia (including MDS transformed AML and relapsed AML after treatment) aged 60 to 75 years old; 2. MDS and IPSS graded as moderate risk, or MDS-EB-1 and MDS-EB-2 as refractory anemia and RAEB (including mds-eb-1 and mds-eb-2); 3. No serious complications, such as liver failure, renal failure, heart failure; 4. For the patients whose peripheral blood leukocytes were less than 50x10^9/L at the beginning of induction therapy, no chemical therapy was performed except hydroxyurea before induction therapy; 5. There was no uncontrollable hypertension and diabetes; 6. Must be able to understand the protocol, follow the doctor's orders and obtain informed consent signed by the patient or family member.
Exclusion criteria
Exclusion criteria: 1. Those who are allergic to the test drug; 2. Use other anti leukemia therapy, such as radiotherapy, cell immunotherapy; 3. Participate in other clinical trials at the same time; 4. Patients with other types of malignant tumors; 5. Have psychosis or other diseases, unable to fully cooperate with the trial treatment or follow-up requirements; 6. Patients with uncontrolled active infection; 7. The active period of uncontrolled infectious diseases, such as HIV, HBV, HCV, active tuberculosis, etc; 8. Patients with central nervous system leukemia; 9. The investigator evaluated those who could not participate in the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete response rate ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Drug safety; | — |
Countries
China
Contacts
Public ContactYan Jinsong
The Second Affiliated Hospital of Dalian Medical University
Outcome results
None listed