High-grade glioma
Conditions
Interventions
experimental group:Ventricle opening during surgery
control group:Ventricle not opening during surgery
Sponsors
Nanfang Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Primary high-grade glioma, which was confirmed as high-grade glioma by postoperative pathology (WHO grade III and IV); 2. Preoperative MRI examination showed that the tumor was close to the ventricle (the minimum distance between abnormal T2/FLAIR signal and the lateral ventricle = 60, 18-70 years old, male or female; 4. All patients underwent craniotomy to remove the tumour, and the postoperative follow-up compliance was good; 5. Recieved standard postoperative radiotherapy and chemotherapy; 6. Sign the informed consent instrument.
Exclusion criteria
Exclusion criteria: 1. Preoperative MRI examination showed that the tumor involved the ventricle (T1 enhanced image abnormal signal communicated with the lateral ventricle); 2. Pregnant and nursing women; 3. Previous history of head surgery; 4. 5 years of previous history of other systemic malignant tumors; 5. Severe cardiovascular and respiratory diseases.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival time; | — |
Secondary
| Measure | Time frame |
|---|---|
| progression-free survival time;The tumor spread through the central nervous system;hydrocephalus;Postoperative fever;scalp hydrops; | — |
Countries
China
Contacts
Public ContactQi Songtao
Department of Neurosurgery, Nanfang Hospital of Southern Medical University
Outcome results
None listed