Neurological diseases
Conditions
Interventions
Patients with primary hypothyroidism >= 56 years:N/A
Alzheimer's disease group >= 56 years:N/A
Patients with primary hypothyroidism and in need of thyroid hormone replacement therapy >= 56 years:N/A
Healthy subjects, 20-55 years:N/A
Healthy subjects, >= 56 years:N/A
Sponsors
China Medical University
Eligibility
Sex/Gender
All
Age
20 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Analysis of the correlation between aging-related thyroid hormone levels and ApoE4 levels in peripheral blood exosomes. standard constrain: 1) for healthy subjects; 2) Adults aged 20-55 years, regardless of gender. 3) Elderly men and women aged 56 years and over. 2. To analyze the correlation between senile hypothyroidism and ApoE4 level and cognitive function in exosomes. standard constrain: Case group: 1) Patients with primary hypothyroidism (patients diagnosed with primary hypothyroidism after examination of serum thyroid-related hormones, etc.); 2) Aged >= 56 years, regardless of gender. Control group: 1) for healthy subjects; 2) Aged 20-55 years, not limited to men and women. 3. To detect the effect of thyroid hormone on ApoE4 level in exosomes and cognitive function. standard constrain: 1) Patients with primary hypothyroidism (confirmed by examination of serum thyroid-related hormones, etc. (Diagnosed with primary hypothyroidism and confirmed by a clinician as requiring thyroid hormone replacement therapy); 2) Aged >= 56 years, regardless of gender. 4. Examine the role of ApoE4 levels in peripheral blood exosomes in the identification of AD disease. standard constrain: 1) AD patients (confirmed according to IWG-2 clinical AD diagnostic criteria) 2) Aged >= 56 years, regardless of gender.
Exclusion criteria
Exclusion criteria: 1. Analysis of the correlation between aging-related thyroid hormone levels and ApoE4 levels in peripheral blood exosomes. Exclusion criteria: 1) Exclude those with major organic disease, thyroid disease or neuropsychiatric disease. 2) Meet the inclusion criteria but refuse to sign the informed consent. 2. To analyze the correlation between senile hypothyroidism and ApoE4 level and cognitive function in exosomes. Exclusion criteria: Case group: 1) Exclude those with major organic lesions. Control group: 2) Meet the inclusion criteria but refuse to sign the informed consent. 3. To detect the effect of thyroid hormone on ApoE4 level in exosomes and cognitive function. Exclusion criteria: 1) Exclude those with major organic lesions. 2) Meet the inclusion criteria but refuse to sign the informed consent. 4. Examine the role of ApoE4 levels in peripheral blood exosomes in the identification of AD disease. Exclusion criteria: 1) Exclude those with major organic lesions. 2) Meet the inclusion criteria but refuse to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Peripheral blood thyroid hormone levels;ApoE4 levels in peripheral blood exosomes;Cognitive function; | — |
Countries
China
Contacts
Public ContactBaoman Li
The First Hospital of China Medical University
Outcome results
None listed