schizophrenia and major depressive disorder
Conditions
Interventions
experimental group:Gene-guided treatment
control group:Treatment as usual
Sponsors
Institute of Mental Health of Beijing University's Sixth Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria for patients with schizophrenia: (1) Each patient should be diagnosed as schizophrenia according to the DSM-IV criteria; (2) Aged 18 to 60 years; (3) Both the patients and their parents are Chinese Han descents; (4) The total scores of the PANSS are more than 60(each item is scored from 1 to 7); (5) The patient can complete the 12-week follow-up, and agreed to cooperate with the researcher to complete the treatment follow-up on time; (6) All of the patients or their guardians should give the written informed consent. 2. Inclusion criteria for patients with major depressive disorder (1) Aged 18-60 years; (2) Both the patients and their parents are Chinese Han descents; (3) Outpatient or inpatient; (4) Depression was clearly diagnosed by 2 attending psychiatrists and above; (5) The baseline Hamilton depression scale (HAMD) was >= 18; (6) The patient can complete the 12-week follow-up, and agreed to cooperate with the researcher to complete the treatment follow-up on time; (7) All of the patients or their guardians should give the written informed consent.
Exclusion criteria
Exclusion criteria: 1. Exclusion criteria for patients with schizophrenia: (1) Patients with pregnancy or breast-feeding; (2) Patients with more than 5 minutes of loss of consciousness; (3) Patients with severe or unstable physical diseases; (4) Patients who have received electroconvulsive therapy in the past six months (5) Patients that regular use addictive drugs for nearly one month; (6) Patients with other mental disorders according to DSM-IV criteria. 2. Exclusion criteria for patients with major depressive disorder (1) Patients with pregnancy or breast-feeding; (2) Patients with more than 5 minutes of loss of consciousness; (3) Patients with severe or unstable physical diseases; (4) Patients who have received electroconvulsive therapy in the past six months (5) Patients that regular use addictive drugs for nearly one month; (6) Patients with other mental disorders according to the DSM-IV criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| PANSS;Hamilton Depression Scale; | — |
Countries
China
Contacts
Public ContactYue Weihua
Institute of Mental Health of Beijing University's Sixth Hospital
Outcome results
None listed