breast cancer
Conditions
Interventions
Single arm:Radiofrequency ablation
Sponsors
The First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Female, older than 18 years; 2. Pathological diagnosis of breast cancer by thick needle puncture without distant metastasis; 3. B-ultrasound or molybdenum target confirmed as a single breast neoplasm with no suspected dispersed intraductal cancer components; 4. The diameter of the tumor measured by B-ultrasound in the supine position less than 3 cm. The distance of the tumor from chest wall, nipple and skin more than 0.5 cm; 5. Karnofsky score >= 70%; 6. Informed consent.
Exclusion criteria
Exclusion criteria: 1. Evidence of extensive intraductal carcinogenesis in invasive breast cancer; 2. Multifocal breast tumors; 3. Duration of pregnancy or lactation; 4. Patients with coagulative disease, chronic liver disease or renal failure; 5. HIV infection or the presence of AIDS-related diseases, or severe acute and chronic diseases; 6. Severe active infections (>grade 2, NCI-CTCAE 3.0); 7. People with low compliance assessed by researchers; 8. Epilepsy patients requiring medication (e.g. steroids or antiepileptic drugs); 9. Psychological or psychiatric disorders such as drug abuse or the possibility that patients may interfere with research compliance; 10. Receiving systemic chemotherapy, targeted drug therapy or local radiotherapy; 11. Any situation that is unstable or may endanger the safety and compliance of patients in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Complete ablation rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Disease-freesurvival, DFS;Overallsurvival, OS;T cell;NK cell;Immune cells; | — |
Countries
China
Contacts
Public ContactWang Shui
The First Affiliated Hospital of Nanjing Medical University
Outcome results
None listed