novel coronavirus pneumonia (COVID-19)
Conditions
Interventions
control group:Standard treatment
experimental group:Standard treatment and methylprednisolone for injection
Sponsors
Wuhan Pulmonary Hosptial
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Adults (defined as age >= 18 years); 2. Patients with new type of coronavirus infection confirmed by PCR / serum antibodies; 3. The time interval between symptom onset and random enrollment is within 10 days.The onset of symptoms is mainly based on fever. If there is no fever, cough or other related symptoms can be used; 4. Imaging confirmed pneumonia; 5. In the state of no oxygen at rest, the patient's blood oxygen saturation SPO2 = 24) or oxygenation index <= 300mmHg.
Exclusion criteria
Exclusion criteria: 1. Known to receive hormone therapy orally or intravenously; 2. Hormone therapy is needed due to concomitant disease upon admission; 3. Patients with diabetes are receiving oral medication or insulin therapy; 4. Known contraindications to dexamethasone or other excipients (such as refractory hypertension; epilepsy or delirium and glaucoma); 5. Known active gastrointestinal bleeding in the past 3 months; 6. Known difficulties in correcting hypokalemia; 7. Known secondary bacterial or fungal infections; 8. Known immunosuppressive status (such as chemotherapy / radiotherapy / HIV infection within one month after surgery); 9. The clinician thinks that participating in the trial may cause patient damage (such as severe lymphocyte reduction); 10. The patient may be transferred to a non-participating hospital within 72 hours.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ECG;Chest imaging;Complications;vital signs;NEWS2 score; | — |
Countries
China
Contacts
Public ContactRonghui Du
Wuhan Pulmonary Hospital
Outcome results
None listed