Knee osteoarthritis
Conditions
Interventions
epidural analgesia group:Epidural analgesia device(Henan ostrich Medical Equipment Co., Ltd., China), Ropivacaine,Morphine Hydrochloride,Saline
local infiltration(extra-articular) sustained-release analgesia group:Disposable local infiltration analgesia device(Beijing Tongji Hengyuan Medical Technology Co., Ltd., China),Ropivacaine,Morphine H
Sponsors
Department of orthopaedic surgery, The Fourth Affiliated Hospital, Zhejiang University, School of Medicine, Yiwu 322000, ZheJiang, China
Eligibility
Sex/Gender
All
Age
50 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) patients requiring the bilateral knee arthroplasty due to the degenerative osteoarthritis, the conservative treatment is ineffective; (2) The patients receiving the epidural anesthesia, American Society of Anesthesiologists (ASA) classification (anesthesia risk assessment) is the I ~ II level; (3) the patients willing to receive the staged bilateral surgery, the interval of the operation will be more than 3 months; (4) aged 50 to 80 years; (5) the patients have the ability to sign informed consent.
Exclusion criteria
Exclusion criteria: 1. The patient unwilling to be enrolled in the trial; 2. The patient has a cognitive or sensory impairment and cannot understand the visual analogue score; 3. allergic to anesthetic drugs and sulfa; 4. Failure of combined spinal and epidural anesthesia; 5. The patient had previous surgery on the knee joint or had a history of knee injury.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Visual analogure score;Postoperative consumption of remedial morphine hydrochloride;Range of knee motion; | — |
Secondary
| Measure | Time frame |
|---|---|
| Quadriceps strength;Incidence of postoperative nausea and vomitting; | — |
Countries
China
Contacts
Public ContactLe-Yi Huang
Department of orthopaedic surgery, The Fourth Affiliated Hospital, Zhejiang University, School of Medicine, Yiwu 322000, ZheJiang, China
Outcome results
None listed