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The dynamic alteration of gut microenvironment of moderate to severe UC patient under glucocorticoid induction of remission: an observational study

The dynamic alteration of gut microenvironment of moderate to severe UC patient under glucocorticoid induction of remission: an observational study

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2000029648
Enrollment
Unknown
Registered
2020-02-09
Start date
2019-11-26
Completion date
Unknown
Last updated
2020-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Ulcerative Colitis

Interventions

GC treatment:1mg/kg prednison or other GC with same dose
Health Control:NO intervention

Sponsors

Peking Union Medical College Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Aged 18-65 years, meet the diagnosis criteria of moderate to severe UC according to IBD consensus 2018

Exclusion criteria

Exclusion criteria: 1. History of probiotics or antibiotics administration within last four weeks; 2. Complicated with Tumors, severe infectious diseases, and abnormal of renal or liver function; 3. Can not afford endoscopy; 4. Can not understand this clinical research.

Design outcomes

Primary

MeasureTime frame
Fecal microbiota 16S rRNA;Fecal microbiota metagenomics;—

Secondary

MeasureTime frame
Fecal bile acid metabolites;Mucosal RNAseq;serological tests;—

Countries

China

Contacts

Public ContactJingnan Li

Peking Union Medical College Hospital

lijn2008@163.com+86 10 69154804

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026