locally advanced pancreatic cancer
Conditions
Interventions
single arm:High intensity focused ultrasoud combined with chemotherapy
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
30 Years to 76 Years
Inclusion criteria
Inclusion criteria: 1. Puncture biopsy confirmed pancreatic adenocarcinoma; 2. According to the NCCN Guidelines (2018.V1), radiological examinations identified unresectable locally advanced pancreatic cancer: (1) artery: Head/uncinate process of pancreas: 1) Tumors invade superior mesenteric artery more than 180 degrees; 2) Tumors invade abdominal trunk more than 180 degrees; 3) Invasion of the first jejunal branch of superior mesenteric artery by tumors. (2) Pancreatic body and tail: 1) Tumors invade superior mesenteric artery or celiac trunk more than 180 degrees; 2) Tumors invade the abdominal trunk and aorta; (3) vein: Head/uncinate process of pancreas: 1) Invasion or embolization of tumors (thrombus or thrombus) leading to unresectable reconstruction of superior mesenteric vein or portal vein; 2) The proximal jejunal drainage branch of most superior mesenteric veins invaded by tumors. Pancreatic body and tail: Invasion or embolization of tumors (thrombus or thrombus) leading to unresectable reconstruction of superior mesenteric vein or portal vein. (3) Ultrasound energy can spread completely. (4) Aged 18 to 75 years old male and female. (5) Blood routine: neutrophils (>1.5 *10^9/L), platelets (>100 *10^9/L) and hemoglobin (>90 g/L). (6) There were no serious abnormalities of blood system, heart and lung function and immune deficiency (refer to their respective standards). (7) Voluntary participation and signing of informed consent; (8) Ability to comply with research visits and other program requirements.
Exclusion criteria
Exclusion criteria: (1) Patients with connective tissue disorder or any foreign bodies in ultrasound energy channels. (2) Central nervous system diseases, psychiatric disorders, unstable angina pectoris, congestive heart failure, severe arrhythmia and other serious uncontrollable diseases. (3) Pregnant and lactating women. (4) Any condition that may impair patient safety or integrity of research data, including serious medical risk factors, medical conditions, and laboratory abnormalities. (5) The patient is unwilling or unable to follow the research procedure, or may be separated from the observation for one course or more during the course of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overall survival;volume of tumor;CA19-9;quality of life;pain score;complications;metastasis;the velocity in large vessel of the tumor; | — |
Countries
China
Contacts
Public ContactLin-xue Qian
Beijing Friendship Hospital, Capital Medical University
Outcome results
None listed