Colorectal cancer
Conditions
Interventions
Control group:Placebo
Sponsors
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Colorectal cancer patients with definite pathological diagnosis; 2. The stage of TNM was diagnosed as stage IV by imaging or pathology, and the metastasis could not be resected; 3. Aged 18-80 years old, gender unlimited; 4. Chemotherapy, pelvic radiotherapy, targeted therapy and immunotherapy have been completed for at least 1 month; 5. The estimated survival time is more than half a year or more; 6. Patients with informed consent and good compliance.
Exclusion criteria
Exclusion criteria: 1. Previous or combined history of other primary malignant tumors; 2. Severe cardiovascular complications, severe liver and kidney dysfunction; 3. The patients with intestinal obstruction can't be treated by oral medicine and need intravenous high energy nutrition 4. Severe malabsorption or other diseases affecting gastrointestinal absorption; 5. Subjects who received any of the following treatments during a specific period prior to enrollment: (1) The patients were treated with antibiotics orally or intravenously within 2 weeks; (2) Receiving intestinal flora regulator (such as Peifeikang, Lactobacillus tablet, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| OS; | — |
Secondary
| Measure | Time frame |
|---|---|
| ESAS;TCM syndrome scale;Gut microbiome; | — |
Countries
China
Contacts
Public ContactYufei Yang
Xiyuan Hospital of China Academy of Chinese Medical Sciences
Outcome results
None listed