pancreatic fistula
Conditions
Interventions
experimental group (octreotide group):The first dose of octreotide was 0.1 mg after the beginning of ventilator-assisted breathing, and then subcutaneously injected every 8 hours. 0.1 mg for 5 days,
control group (saline group):The control group was successfully intubated under anesthesia before operation. After the beginning of ventilator-assisted breathing, the first dose of saline was given, a
Sponsors
Department of Biliary-Pancreatic Surgery, Renji Hospital, School of Medicine, Shanghai Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1) Han nationality; (2) >=18 years and <= 75 years; (3) Elective surgery of pancreaticoduodenectomy (CHILD digestive tract reconstruction); (4) Informed consent and signature of informed consent; (5) The preoperative jaundice index was less than 250umol/L; (6) Chemotherapy and abdominal radiotherapy were not performed within 6 months before operation. (7) No long-term history of adrenocortical hormones and immunosuppressive agents for various reasons; (8) Compliance with ASA Class I-II standards; (9) BMI: 18.5-24.9Kg/m2.
Exclusion criteria
Exclusion criteria: (1) Important organs (such as heart, lung, liver, brain and kidney) dysfunction; (2) Postoperative patients without receiving R0 resection of malignant lesion; (3) Sudden cardio-cerebrovascular accident or other serious postoperative complications caused by non-pancreatic leakage.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood amylase;Amylase in drainage fluid; | — |
Secondary
| Measure | Time frame |
|---|---|
| Liver function;Renal function;Routine blood test;Bacterial culture and drug sensitivity test of drainage fluid; | — |
Countries
China
Contacts
Public ContactHua Rong
Renji Hospital, School of Medicine, Shanghai Jiaotong University
Outcome results
None listed