acute coronary syndrome
Conditions
Interventions
Group 1:PPI
Group 2:H2RA
Group 3:Do not use acid inhibitors
Sponsors
Peking University Third Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Acute coronary syndrome patients admitted to the CCU of the Peking University Third Hospital; 2. CRUSADE score <= 40 points; 3. 18 <= age < 75 years old.
Exclusion criteria
Exclusion criteria: 1. Suffer from gastrointestinal bleeding, acute pancreatitis, reflux esophagitis and other diseases that require PPI therapy upon admission; 2. Suffer from shock status, post-cardiopulmonary resuscitation, cardiopulmonary bypass support, renal replacement therapy, coagulopathy, severe liver disease, thrombocytopenia, astrointestinal surgery and other critical illness states; 3. Peptic ulcer or gastrointestinal bleeding history, inflammatory bowel disease and other autoimmune diseases before admission; 4. Use of PPI or H2RA in one month before admission; 5. Use of antibiotics, probiotics, glucocorticoids, immunosuppressants, anxiolytics, and depression drugs in one month before or after admission; 6. Pregnancy status.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| intestinal flora; | — |
Secondary
| Measure | Time frame |
|---|---|
| metabolites of flora; | — |
Countries
China
Contacts
Public ContactDuan Liping
The Third Hospital of Beijing University
Outcome results
None listed